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Asked by Unregistered on Mon 31, Mar 2008 09:43am :
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I am 63 this year and was menopausal at age 42. At this time my gynaecologist prescribed progesterone and oestrogen tablets
which I took for about 3 years, after which I was prescribed straight oestrogen - no more menstruation, and which I took
until age 57. I have had mamograms every two year since 50 the last one being in end of Sept 2006. A lump has been detected
in my left breast - had a fine needle biopsy but path doctors could not tell whether it was carcinoma or lymphoma. Had a core
biopsy yesterday to get a definite result and having a bone scan today to prove no cancer in rest of body today. The main
reason presented to me for having HRT prescribed seemed to be for the prevention of heart attack and so that I would not
appear too wizened in my old age. By the way there was no history of breast or any other cancer in females on both sides of
my family. Am I victim of HRT? GP's did not bat an eyelid about providing HRT prescriptions for me over the years until
nearly 6 years ago one suggested that if I had no reason to take it try going off it and I did,only to find a lump inside my
left breast nearly six years later. The only after affects were itchy skin for which I used vitamin e cream
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Answer by Dr Bobby V, MD (doctor) on Mon 31, Mar 2008 01:38pm:
Hi,
You took hormone replacement therapy (HRT), and have recently been detected to have breast malignancy.
(?carcinoma, ?lymphoma). You want to know if this is attributable to the hormones you took.
Let us review the results of two large studies that investigated the link between HRT and breast cancer.
The Womens Health Initiative (WHI) trial included over 16,000 postmenopausal women on hormonal therapy. The
trial was stopped in 2002 when data showed an increase in risk of breast cancer, stroke, MI, and deep vein
thrombosis. There was a lower risk of fracture and colorectal cancer among those who took HRT.
The Million Woman Study too reached a similar conclusion - hormone replacement therapy causes a slight
increase in breast cancer. Such cancers were, however, of earlier stage, lower grade, better differentiation,
and were associated with better outcomes than breast cancers detected among women not taking HRT.
An excellent review on the subject is available at: http://www.emasonline.org/content/PDF/The%20Million%20Women%20Study%20and%20breast%20cancer.pdf
Lymphoma is not known to be associated with HRT.
All the best.
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